Results 151 to 160 of about 15,732,617 (305)

time domain

open access: yes
Citation: 'time domain' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.08433 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Abstract control rules and their use in domain independent planning [PDF]

open access: yes, 2005
Control rule based planners that take advantage of hand coded domain specific control knowledge currently out-perform fully automatic planners. Generic types have been presented as abstractions of the behaviour of types identified in planning domains and
Murray, Luke Caleb James
core  

Full-wave analysis of reverse saturable absorption in time-domain

open access: yes, 2018
An advanced full-wave time-domain numerical model for reverse saturable absorption (RSA) is presented and verified against established methods. Rate equations, describing atomic relaxations and excitation dynamics, are coupled to Maxwell equations by ...
Alexander V. Kildishev (1611955)   +1 more
core   +1 more source

Dancing with the electrons: time-domain and CW in vivo EPR imaging

open access: yes, 2008
The progress in the development of imaging the distribution of unpaired electrons in living systems and the functional and the potential diagnostic dimensions of such an imaging process, using Electron Paramagnetic Resonance Imaging (EPRI), is traced ...
Subramanian, Sankaran   +1 more
core   +1 more source

Ultrafast pulse propagation time-domain dynamics in dispersive one-dimensional photonic waveguides

open access: yesNanophotonics
Ultrafast pulses, particularly those with durations under 100 fs, are crucial in achieving unprecedented precision and control in light–matter interactions.
Sakin Ahmet Oguz   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A Map of the Outer Gas Disk of the Galaxy with Direct Distances from Young Stars

open access: yesThe Astrophysical Journal
For more than 50 yr, astronomers have mapped the neutral hydrogen gas in the Galaxy assuming kinematically derived distances. We employ the distances of nearby young stars, which trace the gas from which they formed, in longitude–latitude–velocity space ...
Peter Craig   +4 more
doaj   +1 more source

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