Results 61 to 70 of about 2,686,479 (265)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Implementation of wavelet transform based on switched current circuits
Dianzi Jishu Yingyong, 2018 In order to meet the engineering application requirement for low-power and real-time signal processing, an implementation of wavelet transform using switched current(SI) technique is presented in this paper.
Hu Qinchun +5 more
doaj +1 more source
Speech Emotion Recognition through Hybrid Features and Convolutional Neural Network
Applied Sciences, 2023 Speech emotion recognition (SER) is the process of predicting human emotions from audio signals using artificial intelligence (AI) techniques. SER technologies have a wide range of applications in areas such as psychology, medicine, education, and ...
Ala Saleh Alluhaidan +4 more
doaj +1 more source
Atom optics in the time domain
Physical Review A, 1996 Atom-optics experiments are presented using a time-modulated evanescent light wave as an atomic mirror in the trampoline configuration, i.e., perpendicular to the direction of the atomic free fall. This modulated mirror is used to accelerate cesium atoms, to focus their trajectories, and to apply a ‘‘multiple lens’’ to separately focus different ...
Arndt, M. +3 more
openaire +3 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Free Surface Reconstruction for Phase Accurate Irregular Wave Generation
Journal of Marine Science and Engineering, 2018 The experimental wave paddle signal is unknown to the numerical modellers in many cases. This makes it quite challenging to numerically reproduce the time history of free surface elevation for irregular waves.
Ankit Aggarwal +4 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A Late-time Radio Survey of Type Ia-CSM Supernovae with the Very Large Array
The Astrophysical JournalType Ia-CSM supernovae (SNe) are a rare and peculiar subclass of thermonuclear SNe characterized by emission lines of hydrogen or helium, indicative of high-density circumstellar medium (CSM). Their implied mass-loss rates of ∼10 ^−4 –10 ^−1 M _⊙ yr ^−1 (
Olivia Griffith +10 more
doaj +1 more source
Time-Domain Speaker Extraction Network [PDF]
2019 IEEE Automatic Speech Recognition and Understanding Workshop (ASRU), 2019 Speaker extraction is to extract a target speaker's voice from multi-talker speech. It simulates humans' cocktail party effect or the selective listening ability. The prior work mostly performs speaker extraction in frequency domain, then reconstructs the signal with some phase approximation.
Chenglin Xu +3 more
openaire +2 more sources