Results 91 to 100 of about 2,686,479 (265)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Time-domain vector ptychography
Optics ExpressWe demonstrate the reconstruction of the instantaneous polarization state of ultrafast laser pulses through vectorial time-domain ptychography. We introduce the formalism, investigate the algorithm’s capacities through simulations, and finally validate it by reconstructing several polarization states from experiments.
T. Schweizer +3 more
openaire +2 more sources
FEBS Letters, EarlyView.The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile +8 more
wiley +1 more source
Accurate Behavioral Simulator of All-Digital Time-Domain Smart Temperature Sensors by Using SIMULINK
Sensors, 2016 This study proposes a new behavioral simulator that uses SIMULINK for all-digital CMOS time-domain smart temperature sensors (TDSTSs) for performing rapid and accurate simulations. Inverter-based TDSTSs offer the benefits of low cost and simple structure
Chun-Chi Chen +2 more
doaj +1 more source
Time-domain braiding of anyons
ScienceAnyons are quasiparticles that keep a robust memory of particle exchanges via a braiding phase factor. When an anyon excitation is emitted toward a quantum point contact (QPC) in a fractional quantum Hall (FQH) fluid, this memory translates into tunneling events that may occur long after the anyon excitation has exited the QPC.
Ruelle, M. +13 more
openaire +4 more sources
Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach
FEBS Letters, EarlyView.The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring +3 more
wiley +1 more source
A Time-Domain CMOS Oscillator-Based Thermostat with Digital Set-Point Programming
Sensors, 2013 This paper presents a time-domain CMOS oscillator-based thermostat with digital set-point programming [without a digital-to-analog converter (DAC) or external resistor] to achieve on-chip thermal management of modern VLSI systems.
Shih-Hao Lin, Chun-Chi Chen
doaj +1 more source
Caching With Time Domain Buffer Sharing
IEEE Transactions on Communications, 2019 35 pages, 9 figures, 2 ...
Wei Chen 0002, H. Vincent Poor
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source