Results 141 to 150 of about 13,838,030 (309)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Issues in Planning Domain Model Engineering
The paper raises some issues relating to the engineering of domain models for automated planning. It studies the idea of a domain model as a formal specification of a domain, and considers properties of that specification.
Vallati, Mauro +2 more
core
Abstract control rules and their use in domain independent planning [PDF]
, 2005 Control rule based planners that take advantage of hand coded domain specific control knowledge currently out-perform fully automatic planners. Generic types have been presented as abstractions of the behaviour of types identified in planning domains and
Murray, Luke Caleb James
core
Dancing with the electrons: time-domain and CW in vivo EPR imaging
, 2008 The progress in the development of imaging the distribution of unpaired electrons in living systems and the functional and the potential diagnostic dimensions of such an imaging process, using Electron Paramagnetic Resonance Imaging (EPRI), is traced ...
Subramanian, Sankaran +1 more
core +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Efficient Time-Domain Dimension Reduction Methods for Simulating Stationary Stochastic Processes
MathematicsThe high-dimensional stochastic space caused by a large number of random variables remains a significant challenge hindering the practical application of stochastic process simulation in engineering.
Guoyu Liu +3 more
doaj +1 more source
Citation: 'time domain' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.08433 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Modelling metallic discontinuities with the non-orthogonal finite difference time domain method
, 2004 Numerical electromagnetic models, such as the finite difference time domain (FDTD) method, have many applications. The authors focus on the non-orthogonal FDTD method, which offers an improved geometric flexibility compared to other standard techniques ...
Nilavalan, R, Railton, CJ, Craddock, IJ
core +1 more source