Results 151 to 160 of about 5,394,829 (294)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Heart Rate Variability Time-Domain Analysis Across Glaucoma Subtypes. [PDF]

Biomedicines
Yoshida Y, Takei H, Ukisu M, Takagi K, Tanito M.   +4 more
europepmc   +1 more source

Finite-difference time-domain analysis of increased penetration depth in optical coherence tomography by wavefront shaping. [PDF]

Biomed Opt Express, 2018
Kim JU, Choi H, Park Y, Shin J.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Heart rate variability reveals graded task difficulty effects and sensitization dynamics in anticipatory psychological stress via time-domain analysis. [PDF]

J Physiol Anthropol
Jian Z, Huang J, Shi F, Shimomura Y.
europepmc   +1 more source

On Time Domain Analysis of Photoplethysmogram Signals for Monitoring Heat Stress. [PDF]

Sensors (Basel), 2015
Elgendi M, Fletcher R, Norton I, Brearley M, Abbott D, Lovell NH, Schuurmans D.   +6 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Time-Domain Analysis of Chest Impedance for Venous Air Embolism Detection: An Open-Source Software Tool and Single-Cadaver Pilot Study. [PDF]

Cureus
Marcellino C, Johnston M, Robinson N, Abcejo AS.   +3 more
europepmc   +1 more source

Time-domain analysis of scrotal thermoregulatory impairment in varicocele. [PDF]

Front Physiol, 2014
Ismail E, Orlando G, Pompa P, Gabrielli D, Di Donato L, Cardone D, Merla A.   +6 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source