Results 181 to 190 of about 33,733,084 (204)

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

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Performance Evaluation of Epileptic Seizure Prediction Using Time, Frequency, and Time–Frequency Domain Measures

Processes, 2021
Junteng Zheng, Lizhi Peng, Debiao Ma
exaly  

Discontinuous Galerkin Time-Domain Methods for Multiscale Electromagnetic Simulations: A Review

Proceedings of the IEEE, 2013
Qing Huo Liu, Jiefu Chen
exaly  

Terahertz Time-Domain Spectroscopy for Material Characterization

Proceedings of the IEEE, 2007
Mira Naftaly, Robert E Miles
exaly  

Calculations of the dispersive characteristics of microstrips by the time-domain finite difference method

IEEE Transactions on Microwave Theory and Techniques, 1988
K K Mei
exaly  

Analysis of heat flow in layered structures for time-domain thermoreflectance

Review of Scientific Instruments, 2004
David G Cahill
exaly  

A New Framework for CNN-Based Speech Enhancement in the Time Domain

IEEE/ACM Transactions on Audio Speech and Language Processing, 2019
Deliang Wang, Ashutosh Pandey
exaly