Results 51 to 60 of about 37,226,459 (242)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A New Costing System in Hospital Management: Time-Driven Activity Based Costing: A Narrative Review

Journal of Evidence Based Health Policy, Management & Economics, 2018
Background: Changes in the hospital environment, technology, and service delivery as well as the increased share of overhead costs have motivated hospital managers to look for useful means of calculating costs.
Sina Etemadi, Behzad Mohammadi, Mohammad Javad Akbarian Bafghi, Marjan Hedayati Poor, Mohammad Tasavon Gholamhoseini   +4 more
doaj  

Weighted Activity and Costing of Surveillance and Control in Animal Epidemiology

ITM Web of Conferences, 2013
Activity based modeling and simulation is a very promising field. It has recently demonstrated its potential from modeling software development methods [9] to the design of low energy sensors.
Duboz Raphaël
doaj   +1 more source

A Time-Driven Activity-Based Costing Analysis of Emergency Department Scribes

Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 2019
Objective: To apply time-driven activity-based costing (TDABC) methodology to determine emergency medicine physician documentation costs with and without scribes.
Heather A. Heaton, MD, David M. Nestler, MD, MS, William J. Barry, ME, MBA, Richard A. Helmers, MD, Mustafa Y. Sir, PhD, Deepi G. Goyal, MD, Derek A. Haas, MBA, Robert S. Kaplan, PhD, Annie T. Sadosty, MD   +8 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

An exploration of the factors affecting the diffusion of Advanced Costing techniques: a comparative analysis of two surveys (1996-2005) [PDF]

The issue of cost calculation has been largely debated in the last years under the pressure of the perceived lost of relevance of the so called "traditional cost accounting approaches".
Cinquini, Lino, Marelli, Alessandro, Tenucci, Andrea, Collini, Paolo   +3 more
core   +2 more sources

The Impact of the Magnitude of Overhead Costs on the Difference Between ABC and TDABC Systems

Foundations of Management, 2019
The objective of this study is to investigate the impact of the magnitude of overhead costs on the results of ABC and TDABC differences. A quantitative research method was used and data were gathered through an extensive literature review. A total of 170
Tarzibashi Omar Fikrat Fateh, Ozyapici Hasan   +1 more
doaj   +1 more source

The Time-Driven Activity-Based Costing Model for a Small Startup in Indonesia

Binus Business Review, 2020
The research proposed a Time-Driven Activity-Based Costing (TDABC) model for cost and human capital analysis in a small startup in Indonesia. TDABC discussed and illustrated the integration of capabilities into cost and performance in startups.
Dewi Fitriasari, Naoko Kawahara
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source