Results 111 to 120 of about 743,834 (304)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Subsecond total-body imaging using ultrasensitive positron emission tomography. [PDF]

, 2020
A 194-cm-long total-body positron emission tomography/computed tomography (PET/CT) scanner (uEXPLORER), has been constructed to offer a transformative platform for human radiotracer imaging in clinical research and healthcare. Its total-body coverage and
Badawi, Ramsey D, Cherry, Simon R, Qi, Jinyi, Shi, Hongcheng, Xie, Zhaoheng, Zhang, Xuezhu   +5 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Age-Related Differences in the Physical and Physiological Demands during Small-Sided Games with Floaters

Sports, 2019
The purpose of this study was to compare the physical and physiological demands of a small-sided game (SSG) in three different age groups (senior, under-19 [U-19] and under-17 [U-17]) belonging to the same academy.
Alberto Rábano-Muñoz, Jose Asian-Clemente, Eduardo Sáez de Villarreal, Jack Nayler, Bernardo Requena   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Method for Using Functional Near-Infrared Spectroscopy (fNIRS) to Explore Music-Induced Brain Activation in Orchestral Musicians in Concert

Sensors
The act of performing music may induce a specific state of mind, musicians potentially becoming immersed and detached from the rest of the world. May this be measured? Does this state of mind change based on repetition?
Steffen Maude Fagerland, Andreas Løve, Tord K. Helliesen, Ørjan Grøttem Martinsen, Mona-Elisabeth Revheim, Tor Endestad   +5 more
doaj   +1 more source

GPS-Based Evaluation of Activity Profiles in Elite Downhill Mountain Biking and the Influence of Course Type [PDF]

, 2013
This study aimed to profile the activity patterns of elite downhill (DH) mountain bikers during off-road descending, and to determine the influence of course types on activity patterns. Six male elite DH mountain bikers (age 20 ± 2 yrs; stature 178.8 ± 3.
Hurst, Howard Thomas
core  

Real-Time Automatic Fetal Brain Extraction in Fetal MRI by Deep Learning

, 2017
Brain segmentation is a fundamental first step in neuroimage analysis. In the case of fetal MRI, it is particularly challenging and important due to the arbitrary orientation of the fetus, organs that surround the fetal head, and intermittent fetal ...
Erdogmus, Deniz, Estroff, Judy A., Gholipour, Ali, Hashemi, Seyed Raein, Ouaalam, Abdelhakim, Salehi, Seyed Sadegh Mohseni, Velasco-Annis, Clemente, Warfield, Simon K.   +7 more
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source