Results 191 to 200 of about 1,155,062 (264)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

S2V-DREME: a time-resolved slice-to-volume MR image reconstruction framework with dynamic reconstruction and motion estimation. [PDF]

Phys Med Biol
Qian X, Shao HC, Deng J, Dai Y, Zhang Y.
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Attenuation of typical sex differences in the time-resolved functional connectivity of the fusiform gyrus in autism

Floris D, Saccaro L, Delavari F, Strzelczyk D, Vieira BH, Elleaume C, Pretzsch C, Ecker C, Banaschewski T, Holt R, Baron-Cohen S, BOURGERON T, Charman T, Loth E, Murphy D, Buitelaar J, Beckmann C, De Ville DV, Langer N.   +18 more
europepmc   +2 more sources

Thermally Modulated Metasurface Sensor for Dynamic and Time-Resolved Isolation of Extracellular Vesicles. [PDF]

Adv Mater
Kucuk BN, Yilmaz EG, Aslan Y, Ece E, Erdem Ö, Gungen MA, Öztürk BÖ, Inci F.   +7 more
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Time-Resolved Dynamics of Semiconductor Nanolaser via Four-Wave Mixing Gating. [PDF]

ACS Photonics
Monti F, Madiot G, Modica G, Beaudoin G, Pantzas K, Sagnes I, Yacomotti AM, Raineri F.   +7 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

A time-resolved high-throughput screening of fission yeast deletion mutants for oxidative stress resistance. [PDF]

Microb Cell
Pirsalehi M, Islam RA, Ng K, Xintarakou O, Harold Thorpe P, Rallis C.   +5 more
europepmc   +1 more source