Results 81 to 90 of about 1,155,062 (264)
Time-Resolved Chiral Vibrational Spectroscopy
CHIMIA, 2009 Advances in infrared laser technology and detection sensitivity have made time-resolved chiral vibrational spectroscopy experimentally feasible. Here we describe our recent efforts in detecting, for the first time, transient vibrational circular
Jan Helbing, Mathias Bonmarin
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Constant Matrix Element Approximation to Time-Resolved Angle-Resolved Photoemission Spectroscopy
Photonics, 2016 We discuss several issues associated with employing a constant matrix element approximation for the coupling of light to multiband electrons in the context of time-resolved angle-resolved photoemission spectroscopy (TR-ARPES).
James K. Freericks, H. R. Krishnamurthy
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Attosecond time-resolved photoelectron holography
Nature Communications, 2018 Field induced tunneling is one of the fundamental processes of light-matter interaction. Here the authors reconstruct the temporal properties of tunneling using two-color electron holography with attosecond time resolution using argon atoms.
G. Porat +10 more
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On Two-Dimensional Rangefinding Using a ∼1 nJ/∼100 ps Laser Diode Transmitter and a CMOS SPAD Matrix
IEEE Photonics Journal, 2018 A potentially compact 2-D range profiler for noncooperative targets with a distance range of >10 m is demonstrated. A laser diode utilizing enhanced gain switching is used as a transmitter to provide short, high-energy optical pulses (∼1 nJ&
Lauri W. Hallman +3 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
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