Results 81 to 90 of about 1,097,268 (266)

Time-Resolved Chiral Vibrational Spectroscopy

CHIMIA, 2009
Advances in infrared laser technology and detection sensitivity have made time-resolved chiral vibrational spectroscopy experimentally feasible. Here we describe our recent efforts in detecting, for the first time, transient vibrational circular
Jan Helbing, Mathias Bonmarin
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Constant Matrix Element Approximation to Time-Resolved Angle-Resolved Photoemission Spectroscopy

Photonics, 2016
We discuss several issues associated with employing a constant matrix element approximation for the coupling of light to multiband electrons in the context of time-resolved angle-resolved photoemission spectroscopy (TR-ARPES).
James K. Freericks, H. R. Krishnamurthy
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Attosecond time-resolved photoelectron holography

Nature Communications, 2018
Field induced tunneling is one of the fundamental processes of light-matter interaction. Here the authors reconstruct the  temporal properties of tunneling using two-color electron holography with attosecond time resolution using argon atoms.
G. Porat, G. Alon, S. Rozen, O. Pedatzur, M. Krüger, D. Azoury, A. Natan, G. Orenstein, B. D. Bruner, M. J. J. Vrakking, N. Dudovich   +10 more
doaj   +1 more source

On Two-Dimensional Rangefinding Using a ∼1 nJ/∼100 ps Laser Diode Transmitter and a CMOS SPAD Matrix

IEEE Photonics Journal, 2018
A potentially compact 2-D range profiler for noncooperative targets with a distance range of >10 m is demonstrated. A laser diode utilizing enhanced gain switching is used as a transmitter to provide short, high-energy optical pulses (∼1 nJ&
Lauri W. Hallman, Sahba Jahromi, Jussi-Pekka Jansson, Juha Kostamovaara   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source