Results 31 to 40 of about 89,053,365 (296)

Time to market evaluation for new chemical entities in Italy: a critical analysis of the period 2018-2024

open access: yesGlobal & Regional Health Technology Assessment
Objective: This study aims to provide an up-to-date analysis, for new chemical entities on the market, on the timing of pricing and reimbursement (P&R) in Italy, covering the entire period of activity (from September 2018 to January 2024) of the last ...
Alessandro Tedesco   +4 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

open access: yesFEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey   +4 more
wiley   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin   +11 more
wiley   +1 more source

TIME-ON-MARKET IN CHINESE CONDOMINIUM PRESALES

open access: yesInternational Journal of Strategic Property Management, 2018
The condominium presale market is characterized by information asymmetry between the developer and potential buyers. A condominium developer faces conflicting incentives to sell units quickly at a lower price to generate cash and sales momentum versus to hold prices high and endure longer marketing time to maximize revenues and maintain the property’s ...
Zhou, Xiaorong   +2 more
openaire   +3 more sources

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito   +8 more
wiley   +1 more source

Time-Sharing Trading Price Formation Mechanism and Model of China’s Mid to Long-Term Electricity Market

open access: yesZhongguo dianli, 2023
The time-sharing trading of mid to long-term electricity market is one of the important reform measures for China's electricity market. Aiming at the unreasonable and imperfect problem of current time-sharing trading price formation mechanism, a novel ...
Shanshan HUANG   +5 more
doaj   +1 more source

Safety of Prescription Nonsteroidal Anti‐inflammatory Drugs in Adults With Inflammatory Bowel Disease: Data From a Large Administrative Claims Cohort

open access: yesArthritis Care &Research, EarlyView.
Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer   +4 more
wiley   +1 more source

Text‑Mining in Streams of Textual Data Using Time Series Applied to Stock Market

open access: yesActa Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2018
Each day, a lot of text data is generated. This data comes from various sources and may contain valuable information. In this article, we use text mining methods to discover if there is a connection between news articles and changes of the S&P 500 ...
Pavel Netolický   +2 more
doaj   +1 more source

Black Market International CV [PDF]

open access: yes, 2002
CV for the Black Market International artist collective.

core  

Perceived Impacts and Predictors of Cannabis Products Used by Patients with Rheumatologic Conditions in Alberta, Canada: A Multivariable Analysis of Cross‐Sectional Survey Data

open access: yesArthritis Care &Research, EarlyView.
Objective This study aimed to characterize cannabis product choices (cannabinoid content and formulation) among patients with rheumatologic conditions and their associations with patient factors, patient‐reported perceived side effects, and positive impacts.
Susan Zhang   +10 more
wiley   +1 more source

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