Results 141 to 150 of about 18,915,989 (297)
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
, 2013 There are two models that can be used in estimating portfolio beta: constant risk market model and time varying risk market model. The purpose of this research is to know the difference constant risk market model and time varying risk market model in ...
Pratikto Heri
core
Local Constant Likelihood Estimation for Beta Distribution with Time Varying Parameters
ThisresearchwassupportedbyprojectsPID2020-116294GB-I00andPID2023148158OB-I00 (founded by MICIU/AEI/10.13039/501100011033 and European Union NextGenerationEU/PRTR), by AGAUR under grant 2021 SGR 00613, and by UPC under AGRUPS-2022 and AGRUPS-2023. Nihan Acar-Denizli is a Serra-Húnter fellow.
Acar Denizli, Nihan +1 more
openaire +2 more sources
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
TIME-VARYING COUNTRY BETA APPROACH IN MODELLING
Pressacademia, 2015 Ahmet Kerem Özdemir +1 more
openaire +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Time-Varying Beta Estimators in the Mexican Emerging Market
, 2011 The authors acknowledge financial support from Ministerio de Ciencia e Innovación under research grants ECO2009-09120, ECO2008-00777/ECON, ECO2008-02599 and ECO2011- 29751, and from Dpto. de Educación, Universidades e Investigación del Gobierno Vasco under research grants IT-313-07 and IT-241-07.
Nieto Domenech, Belén +2 more
openaire +2 more sources