Results 111 to 120 of about 19,330,588 (265)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Time-varying conditional Johnson SU density in value-at-risk (VaR) methodology [PDF]

open access: yes
Stylized facts on financial time series data are the volatility of returns that follow non-normal conditions such as leverage effects and heavier tails leading returns to have heavier magnitudes of extreme losses.
Cayton, Peter Julian A., Mapa, Dennis S.
core  

A Square-Root Second-Order Extended Kalman Filtering Approach for Estimating Smoothly Time-Varying Parameters. [PDF]

open access: yesMultivariate Behav Res, 2022
Fisher ZF   +5 more
europepmc   +1 more source

Formation Consensus Control Method With Time-Varying Parameters Based on Virtual Leader

open access: yesInternational Journal of Aerospace Engineering
A method of formation pattern alternation and consistent flight control in complex battlefield environment is put forward, considering the single formation pattern during formation flight and failing to deal with the changeable battlefield environment ...
Hongyun Wang   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

How Robust is Robust Control in the Time Domain? [PDF]

open access: yes
By applying robust control the decision maker wants to make good decisions when his model is only a good approximation of the true one. Such decisions are said to be robust to model misspecification.
Marco P. Tucci
core  

[Design and application of neural electrical stimulation system with time-varying parameters]. [PDF]

open access: yesSheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2021
Yang G, Feng Z, Zheng L, Wang Z.
europepmc   +1 more source

Simulation and Influencing Factors of Soil Water Storage in the Weihe River Basin Under Changing Environment

open access: yesShuitu Baochi Xuebao
[Objective] With the intensified influence of climate change and human activities, the climate and underlying surface conditions of the basins have changed.
YU Kunxia   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

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