Results 121 to 130 of about 12,552,614 (315)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Specialized Large Language Model for Standardization of Locomotive Maintenance Data
Kongzhi Yu Xinxi JishuStandardization is one of the key steps to analyze locomotive overhaul data with a focus on reliability-centered maintenance (RCM). However, traditional manual methods encounter challenges such as small sample sizes, non-standardized data formats ...
CHEN Ao +5 more
doaj +1 more source
Time‐dependent dual effect of NLRP3 inflammasome in brain ischaemia
, 2021 Alejandra Palomino‐Antolín +10 more
openalex +2 more sources
Improving WRF-Fire Wildfire Simulation Accuracy Using SAR and Time Series of Satellite-Based Vegetation Indices [PDF]
, 2022 Yaron Michael +3 more
openalex +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Children's discourse : person, space and time across languages
, 2002 Asta Čekaitė
openalex +2 more sources
NYUS.2: an automated machine learning prediction model for the large-scale real-time simulation of grapevine freezing tolerance in North America [PDF]
, 2023 Hongrui Wang +15 more
openalex +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Sensor Fault Classification Based on Support Vector Machine and Statistical Time-Domain Features
, 2017 Sana Ullah Jan +3 more
openalex +1 more source