Results 121 to 130 of about 11,222,712 (216)

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Time-Dependent Decline in Extraction Ratios for LDL Cholesterol and Fibrinogen During a Single Rheocarna Treatment Session. [PDF]

J Clin Apher
Kukida M, Miyake I, Ito S, Kondo F, Shichijo S, Hirakawa D, Yamada B, Mima T, Yamaguchi O.   +8 more
europepmc   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Best practices for cryo-trapping time-resolved crystallography with the Spitrobot crystal plunger. [PDF]

Protein Sci
Bosman R, Hatton CE, Prester A, Spiliopoulou M, Apostolopoulou V, Tellkamp F, Mehrabi P, Schulz EC.   +7 more
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Weight Loss Outcomes of Routine Dietetic Treatment in Primary Care. [PDF]

Clin Obes
van de Riet A, van Dronkelaar C, van der Meij BS, Meijer WM, de van der Schueren MAE, Langius JAE.   +5 more
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Experiences and coping strategies of time toxicity in young and middle-aged patients with lymphoma: a descriptive qualitative study. [PDF]

Support Care Cancer
Li D, Zheng K, Chen L, Zhang M.
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Force-Vector Pilates Exercises on Functional Performance and Braking Reaction Time in Older Professional Drivers: An Exploratory Feasibility Study. [PDF]

Physiother Res Int
Maciel CCL, Busse AL, Maluly ACS, Alonso AC, Rogatto FBT, Lino MHDS, Filho WJ, Greve JMD.   +7 more
europepmc   +1 more source