Results 231 to 240 of about 21,013,688 (300)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Time

, 2002

core  

The Effect of Hunger on the Likelihood of Glucose Excursions in Adults with Overweight or Obesity: Continuous Glucose Monitoring and Ecological Momentary Assessment Observational Study. [PDF]

JMIR Form Res
Lim B, Githinji P, Liao Y, Szeszulski J, MacMillan Uribe AL, Seguin-Fowler RA, Anderson J, Rethorst CD.   +7 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Is time to plasma exchange the right question in suspected thrombotic thrombocytopenic purpura? [PDF]

Hematol Transfus Cell Ther
Sinha RR.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A simulation-based hybrid causal predictive framework for stockout risk analysis in supply chain. [PDF]

PLoS One
Hafaf E, Alzubi AB, Iyiola K, Aljuhmani HY.   +3 more
europepmc   +1 more source

AI-Assisted Medical Documentation in a Multilingual Swiss Health Care System: Proof-of-Concept Study. [PDF]

JMIR AI
Gładysz M, Fiumedinisi F, Burn F, Rommers N, Giovanoli P, Plock JA.   +5 more
europepmc   +1 more source

The choice of time scales in survival analysis has implications: calendar time versus patients' time-to-event. [PDF]

BMC Med Res Methodol
Vilsmeier J, Büchele G, Rehm M, Unseld T, Rothenbacher D, Beyersmann J.   +5 more
europepmc   +1 more source