Results 91 to 100 of about 1,533,087 (281)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Quantum Time Arrows, Semigroups and Time-Reversal in Scattering [PDF]
, 2002 Two approaches toward the arrow of time for scattering processes have been proposed in rigged Hilbert space quantum mechanics. One, due to Arno Bohm, involves preparations and registrations in laboratory operations and results in two semigroups oriented ...
Bishop, Robert C
core +1 more source
Modeling the Arrows of Time with Causal Multibaker Maps
EntropyWhy do we remember the past, and plan the future? We introduce a toy model in which to investigate emergent time asymmetries: the causal multibaker maps. These are reversible discrete-time dynamical systems with configurable causal interactions. Imposing
Aram Ebtekar, Marcus Hutter
doaj +1 more source
A new species and two newly-recorded species of the genus Micrencaustes (Coleoptera, Erotylidae) from China [PDF]
Biodiversity Data JournalThe genus Micrencaustes Crotch, 1876 (Coleoptera, Cucujoidea, Erotylidae, Erotylinae, Encaustini) includes 44 known species worldwide, 11 species having been reported to occur in China.
Yuhang Yang +3 more
doaj +3 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Opposite Thermodynamic Arrows of Time [PDF]
AIP Conference Proceedings, 1999 A model in which two weakly coupled systems maintain opposite running thermodynamic arrows of time is exhibited. Each experiences its own retarded electromagnetic interaction and can be seen by the other. The possibility of opposite-arrow systems at stellar distances is explored and a relation to dark matter suggested.
openaire +3 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
SSRN Electronic JournalScientific discussions of the arrow of time often get quite confusing due to highly complex systems they deal with. Popular literature then often coveys messages that tend to get lost in translation. The purpose of this note is to demystify the arrow of time by stripping off the unnecessary complexities and thereby simplifying the discussion.
openaire +2 more sources