Results 231 to 240 of about 2,455,455 (282)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Closed-loop SCS and sensing: now and in the future. [PDF]

Pain Med
Chakravarthy K, Orhurhu V, Kallewaard JW, Kapural L, Abd-Elsayed A, Eshraghi Y, Narra LR, Ghosh P, Sheth S, Lee DW, Reddy R, Johanek LM, Gamache JE, Dinsmoor DA, Brinda AK.   +14 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Effects of automated insulin delivery systems on glucose control in subgroups of adults with type 1 diabetes in clinical practice over 2 years in Sweden. [PDF]

Sci Rep
Singh R, Imberg H, Seyed Ahmadi S, Hallström S, Jendle J, Tengmark BO, Folino A, Ekström M, Lind M.   +8 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Clinical outcomes and feasibility of nonthermal, nontumescent ablation for isolated below-the-knee great saphenous vein incompetence. [PDF]

J Vasc Surg Venous Lymphat Disord
Min J, Park SW, Hwang JH, Kim JS, Lee SA, Hwang JJ, Chee HK, Lee YH, Yang WY, Kwon YW.   +9 more
europepmc   +1 more source

Visceral fat rating, but not glycemic variability, is strongly associated with arterial stiffness in non-obese adults with type 1 diabetes. [PDF]

Sci Rep
Kulecki M, Naskret D, Mietkiewska-Dolecka M, Lasowski B, Anderko I, Moska S, Lemanska A, Haras P, Grzelka-Woźniak A, Uruska A, Zozulinska-Ziolkiewicz D.   +10 more
europepmc   +1 more source

Antimicrobial Stewardship in oral and maxillofacial surgery: melting the iceberg. [PDF]

Antimicrob Steward Healthc Epidemiol
Joost I, Kempe M, Eirmbter B, MacKenzie CR, Schorn L.   +4 more
europepmc   +1 more source