Results 221 to 230 of about 4,649,254 (341)

Time Complexity of Link Reversal Routing [PDF]

, 2015
Bernadette Charron-Bost, Matthias Függer, Jennifer L. Welch, Josef Widder   +3 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Association of Unplanned Home Visits, Deaths, Preference for Dying at Home, and Home Deaths With Patient Complexity in a Physician-Led Home Visit Setting: A Secondary Analysis of a Multicenter Prospective Cohort Study. [PDF]

Geriatr Gerontol Int
Sugiyama Y, Watanabe T, Mutai R, Hoshimoto S, Yasuda M, Kanno T, Yoshida S, Tanaka K, Matsumoto M, Matsushima M.   +9 more
europepmc   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Assessing Complexity in Physiological Systems Through Biomedical Signals Analysis II. [PDF]

Entropy (Basel)
Castiglioni P, Faes L, Valenza G, Faini A.   +3 more
europepmc   +1 more source

Simulation Relations, Interface Complexity, and Resource Optimality for Real-Time Hierachical Systems

, 2009
Arvind Easwaran, Insup Lee, Oleg Sokolsky, Madhukar Anand, Linh Thi Xuan Phan   +4 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Development and implementation of measurement-based care for children and youth with complex mental and neurodevelopmental needs: early experiences from Ontario's Extensive Needs Service. [PDF]

Front Psychiatry
Rombos V, Salami ZO, Ferguson G, Baysarowich R, Decker K, Denomey N, Drmic I, Edwards J, Hayawi L, Jeyabalan T, Johansen T, Lui T, Margallo K, Milicevic T, Mitsakakis N, Sutherland S, D'Angiulli A, Webster R, Penner M.   +18 more
europepmc   +1 more source

Multisurface Super-Twisting Sliding Mode Control for Large-Scale Dfig: Robust and Low-Complexity Solution for Time-Varying Disturbance

Sejin Lee, G. S. Kim, Duehee Lee, Young-Hun Kwon   +3 more
openalex   +1 more source