TRPM8 levels determine tumor vulnerability to channel agonists
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo+18 more
wiley +1 more source
Erratum to: Drift analysis and average time complexity of evolutionary algorithms
Jun He, Xin Yao
openalex +1 more source
On the time complexity of 2-tag systems and small universal Turing machines [PDF]
Damien Woods, Turlough Neary
openalex +1 more source
How Do Occupational Sedentary Behavior and Occupational Cognitive Complexity Relate to Cognitive Function? A Cross-Sectional Study. [PDF]
Rizvi N, Lin H, Beiser AS, Spartano NL.
europepmc +1 more source
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine+10 more
wiley +1 more source
Dynamic antenna clustering along with low RF complexity digital beamforming. [PDF]
Haider U+4 more
europepmc +1 more source
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte+10 more
wiley +1 more source
Improved time complexity analysis of the Simple Genetic Algorithm
P. S. Oliveto, C. Witt
semanticscholar +1 more source
Complexity in the Validation of Ground Water Travel Time in Fractured Flow and Transport Systems
Peter B. Davies+2 more
openalex +1 more source
A multiscale stochastic cellular automata model for dispersion of mountain pine beetles. [PDF]
Liu Y, Estep D.
europepmc +1 more source