Results 281 to 290 of about 22,781,989 (354)

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source

Detection of chaotic patterns in dripping faucets through nonlinear dynamic system analysis based on observations using 2700 high-frequency frames. [PDF]

MethodsX
Ladino-Moreno EO.
europepmc   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

FEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law, Yuan Gao, Sravya Kovvali, Pankajavalli Thirugnanasambantham, Vicki H. Wysocki, Brian M. M. Ahmer, Venkat Gopalan   +6 more
wiley   +1 more source

Adaptive Multiresolution and Dedicated Elastic Matching in Linear Time Complexity for Time Series Data Mining

, 2006
Pierre-François Marteau, Gildas Menier
openalex   +2 more sources

Adaptive energy loss optimization in distributed networks using reinforcement learning-enhanced crow search algorithm. [PDF]

Sci Rep
Bharath S, Vasuki A.
europepmc   +1 more source

Algorithms and Time Complexity of the Request-Service Problem. [PDF]

J Comb Optim, 2010
Liu C, Burge L, Blake A.
europepmc   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

A longitudinal study of functional brain complexity in progressive Alzheimer's disease. [PDF]

Alzheimers Dement (Amst)
Zhang R, Aksman L, Wijesinghe D, Ringman JM, Wang DJJ, Jann K, Alzheimer's Disease Neuroimaging Initiative.   +6 more
europepmc   +1 more source

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

FEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma   +7 more
wiley   +1 more source

Research on computing task scheduling method for distributed heterogeneous parallel systems. [PDF]

Sci Rep
Cao X, Chen C, Li S, Lv C, Li J, Wang J.
europepmc   +1 more source