Results 241 to 250 of about 3,046,163 (294)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Research on energy-saving algorithm of HVAC multi-agent system consensus based on event-triggered mechanism. [PDF]

PLoS One
Wu W, Shi S, Lin M, Gong H, Li J.
europepmc   +1 more source

The Influence of Low-Emission Mineral Additives as a Substitute for CEM II and CEM III Cement on the Properties of Cement Mortars. [PDF]

Materials (Basel)
Muzolf P, Rogojsz G, Rudnicki T.
europepmc   +1 more source

Emotionally consistent music melody generation algorithm integrating prompt perception and hyper-network optimization. [PDF]

Sci Rep
Feng Q.
europepmc   +1 more source

An efficient and consistent framework for multi-rank taxonomic identification in wildlife images. [PDF]

Sci Rep
Zhang Q, Ahmed K, Xu C, Khan MI, Wang H.
europepmc   +1 more source

Time-consistent unemployment insurance

, 2021
openaire   +1 more source

Assessing Data Quality in Heterogeneous Health Care Integration: Simulation Study of the AIDAVA Framework.

JMIR Med Inform
Declerck J, Kılıç ÖD, Emir Erol E, Mehryar S, Kalra D, de Zegher I, Celebi R.   +6 more
europepmc   +1 more source