Results 111 to 120 of about 7,849,772 (280)
Some Recent Key Aspects of the DC Global Electric Circuit
AtmosphereThe DC global electric circuit, GEC, was conceived by C.T.R. Wilson more than a century ago. Powered by thunderstorms and electrified shower clouds, an electric current I ~1 kA flows up into the ionosphere, maintaining the ionospheric potential V ~250 kV
Michael J. Rycroft
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Of mice and chickens: Revisiting the RC time constant problem. [PDF]
Hear Res, 2022 Iwasa KH.
europepmc +1 more source
Stability of neutral equations with constant time delays [PDF]
A method was developed for determining the stability of a scalar neutral equation with constant coefficients and constant time delays. A neutral equation is basically a differential equation in which the highest derivative appears both with and without a
Barker, L. K., Whitesides, J. L.
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The Long Outer-Hair-Cell RC Time Constant: A Feature, Not a Bug, of the Mammalian Cochlea. [PDF]
J Assoc Res Otolaryngol, 2023 Altoè A, Shera CA.
europepmc +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Accuracy of the estimations of respiratory mechanics using an expiratory time constant in passive and active breathing conditions: a bench study. [PDF]
Eur J Med Res, 2023 Chen Y, Yuan Y, Zhang H, Li F.
europepmc +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source