Results 131 to 140 of about 1,240,738 (311)
FEBS Open Bio, EarlyView.The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Subcritical Hopf bifurcations in a car-following model with reaction-time delay
, 2005 A nonlinear car-following model of highway traffic is considered, which includes the reaction-time delay of drivers. Linear stability analysis shows that the uniform flow equilibrium of the system loses its stability via Hopf bifurcations and thus ...
Orosz, G, Stepan, G
core
On bounded control of a class of reedforward nonlinear time-delay systems
, 2018 For the global stabilization of a family of feedforward nonlinear time-delay systems with linearized identical oscillators, a saturated feedback control is established based on a special canonical form for the considered system. The proposed control laws
Zhou, B, Lam, J, Yang, X
core +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Stability implications of delay distribution for first-order and second-order systems
, 2009 In application areas, such as biology, physics and engineering, delays arise naturally because of the time it takes for the system to react to internal or external events.
Gabor Kiss +3 more
core
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Trial court delay and the NSW District Criminal Court [PDF]
, 2015 Summary Between 2007 and 2014 trial delay in the NSW District Criminal Court increased 34% for defendants on bail and 44% for those on remand. In 2014 the pending caseload had increased to 1716 trials. This reports finds these results to be due to
Jacqueline Fitzgerald, Don Weatherburn
core