Results 91 to 100 of about 29,209,438 (176)

Controller Design of Multiinput Multioutput Time-Delay Large-Scale System

Abstract and Applied Analysis, 2013
The paper presents a novel feedback linearization controller of nonlinear multiinput multioutput time-delay large-scale systems to obtain both the tracking and almost disturbance decoupling (ADD) performances.
Chia-Wei Lin, Tzuu-Hseng S. Li, Chung-Cheng Chen   +2 more
doaj   +1 more source

Robust $H_{\infty}$ Control of Lurie Nonlinear Stochastic Network Control Systems With Multiple Additive Time-Varying Delay Components

IEEE Access, 2019
In order to further solve the stability problem in the actual network control systems, this paper first simultaneously considers the controlled object system delay and network time delay in the Lurie nonlinear stochastic network control systems.
Hongqian Lu, Chaoqun Guo, Yue Hu
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Robust H∞ filtering for discrete nonlinear stochastic systems with time-varying delay [PDF]

, 2008
This is the postprint version of the article. The official published version can be accessed from the link below - © 2007 Elsevier IncIn this paper, we are concerned with the robust H∞ filtering problem for a class of nonlinear discrete time-delay ...
Liu, Y, Liu, X, Wang, Z, Liu, Yurong, Yurong Liu (9814022), Z Wang (81545), X Liu (7756691), Wang, Zidong, Liu, Xiaohui   +8 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Practical stability of linear switched impulsive system with time delay

Electronic Journal of Differential Equations, 2014
This article concerns the study of practical stability of linear switched impulsive systems with time delay. By using Lyapunov functions and the extended Halanay inequality, we establish sufficient conditions for the practical stability and uniform ...
Shao'e Li, Weizhen Feng
doaj  

Time Parameter Optimization for the Semiconductor Laser-Based Time-Delay Reservoir Computing System

Photonics
Time-delay reservoir computing (RC) systems, particularly those based on semiconductor lasers (SLs), have gained attention due to their low energy consumption, high response rates, and rich nonlinear dynamics.
Qiudi Li, Yushuang Hou, Keqiang Li, Xiaoyu Guo, Chunxia Hu, Dianzuo Yue   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source