Results 211 to 220 of about 1,147,152 (263)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

open access: yesFEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source
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ON THE EVOLUTION OF HANDLING TIME

Evolution, 1985
Etude critique des resultats de Livdahl (1979) et de divers modeles de reactions predateur-proie (dipteres)
Steven A, Juliano, F M, Williams
openaire   +2 more sources

Evolution of Time Coding Systems

Neural Computation, 1999
The auditory and electrosensory systems contain circuits that are specialized for the encoding and processing of microsecond time differences. Analysis of these circuits in two specialists, weakly electric fish and barn owls, has uncovered common design principles and illuminated some aspects of their evolution.
Catherine E. Carr, Matthew A. Friedman
openaire   +2 more sources

Plasmid evolution in the time of antibiotics

Nature Reviews Microbiology
Shimona Starling, Starling Shimona
exaly   +3 more sources

On the evolution of the timing of reproduction

Theoretical Population Biology, 2009
In this paper, we study the evolution of the per capita rate of reproduction as a function of time in the modelling framework introduced by Eskola and Geritz [Eskola, H.T.M., Geritz, S.A.H., 2007. On the mechanistic derivation of various discrete-time population models, Bull. Math. Biol. 69, 329-346].
openaire   +3 more sources

Time evolution

2009
Abstract There is a vast class of interesting physical problems, however, which involve time-dependent Hamiltonians and which are not accessible to perturbative treatment. In this chapter, we discuss some of these systems.
Kenichi Konishi, Giampiero Paffuti
openaire   +1 more source

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