Results 111 to 120 of about 6,758,577 (312)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

ITKids: Is paper IT work more physically variable than computer IT work for children?

, 2007
Children are spending more time than ever on computers for school and leisure and the effect of computer use on their developing musculoskeletal systems is of concern.
Burgess-Limerick, Robin, Straker, Leon M., Coleman, J., Straker, L., Pollock, Clare M. (R20416), Burgess-Limerick, R., Pollock, C., Coleman, Jemma L.   +7 more
core  

Key factors impacting on response time of software vendors in releasing patches for software vulnerabilities [PDF]

, 2012
Software vulnerabilities are a major problem for organizations and society given how pervasive the use of computers and the Internet and networks has become. Computers, the Internet and networks in general are underpinned by operating system software and,
Arjun, K. C.
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Damped Seasonality Factors: Introduction [PDF]

Previous research has shown that seasonal factors provide one of the most important ways to improve forecast accuracy. For example, in forecasts over an 18-month horizon for 68 monthly economic series from the M-Competition, Makridakis et al.
J. S. Armstrong
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Effects of different induction methods and post-activation potentiation on lower limb muscle activation and explosive power

Frontiers in Bioengineering and Biotechnology
ObjectiveTo investigate the acute effects of a different-intensity resistance warm-up on lower limb isokinetic strength, muscle activation, and exercise performance under blood flow restriction.MethodsUsing an isokinetic dynamometer, surface ...
Xingchen Zhang, Yuan Gao, Yang Sun, Enjing Li   +3 more
doaj   +1 more source

Evaluation of Ohio Department of Transportation roadway/weather sensor systems for snow and ice removal operations. Part II, RWIS pavement sensor bench test

, 2003
"May 2003."; Includes bibliographical references (leaf 76).; Final technical report.; Sponsored by Ohio Dept. of Transportation, Office of Maintenance Administration. State job no. 14758(0).
Zwahlen, Helmut T., Ohio Research Institute for Transportation and the Environment. Human Factors and Ergonomics Laboratory.   +1 more
core  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source