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TIME Learning Brief No 3

More information about the TIME (Together in My Education) home-learning programme and materials can be found in open access at: https://wwhomeliteracy.org.za/time/This is the third in a series of learning briefs that explore the implementation of the ...
von Blottnitz, Magali
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A joint effort over a period of time: factors affecting use of urate-lowering therapy for long-term treatment of gout. [PDF]

BMC Musculoskelet Disord, 2016
Richardson JC, Liddle J, Mallen CD, Roddy E, Hider S, Prinjha S, Ziebland S.   +6 more
europepmc   +1 more source

Factors affecting homework completion among students

, 2012
Plan B Paper. 2012. Master of Science in Education- Physics--University of Wisconsin-River Falls. Physics Department. 43 leaves. Includes bibliographical references (leaves 27-28).This study explored factors affecting student homework completion ...
Watkins, Lisa
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Primary care doctors in acute call-outs to severe trauma incidents in Norway - variations by rural-urban settings and time factors. [PDF]

BMC Emerg Med
Myklevoll KR, Zakariassen E, Morken T, Baste V, Blinkenberg J, Bondevik GT.   +5 more
europepmc   +1 more source

Trends in wages, underemployment, and mobility among part-time workers [PDF]

This study examines three trends in the labor market experiences of part-time workers: (1) trends in real earnings; (2) trends in the extent of involuntary part-time work (underemployment); and (3) trends in the rate of exit from part-time work. Data are
J. A. Jacobs
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Temporalities of oxytocin for labour augmentation: a mixed-methods study of time factors shaping labour practices in a busy maternity unit in Tanzania. [PDF]

BMC Pregnancy Childbirth
Kujabi ML, Maembe L, Nkungu D, Maaløe N, D'mello BS, van Roosmalen J, van den Akker T, Konradsen F, Hussein K, Pallangyo E, Skovdal M, Sørensen JB.   +11 more
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source