Results 211 to 220 of about 14,495,444 (299)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Identifying age 26 as a threshold in psychosocial risks associated with child maltreatment among first-time mothers: a cross-sectional study in Japan. [PDF]

Front Public Health
Baba K, Yamasaki S, Niimura J, Nakajima N, Stanyon D, Miyashita M, Yamaguchi S, Nakanishi M, Kita S, Hiraiwa-Hasegawa M, Ando S, Kasai K, Sawyer SM, Nishida A.   +13 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Clinician factors influencing decision-making in emergency general surgery (EGS): a scoping review protocol. [PDF]

BMJ Open
Groundwater E, Bisset CN, Bradley R, John-Charles R, Maeda Y, McKee T, Moug SJ.   +6 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Perceptions of the Likelihood and Importance of Physical Activity Outcomes at 14 Years Affects Physical Fitness at 17 Years. [PDF]

Child Care Health Dev
Timler A, Chivers P, Parker H, Rose E, Tan J, Hands B, Plumb MS.   +6 more
europepmc   +1 more source

Time estimation and personal factors

The Japanese journal of psychology, 1967
openaire   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Efficacy of Gonadotropin Therapy to Induce Spermatogenesis and Fertility in Men with Pathologic Gonadotropin Deficiency.

J Clin Endocrinol Metab
Gialouris JV, Conway AJ, Idan A, Savkovic S, Hermosilla R, Muir CA, Bacha F, Zhang T, Hou W, Jayadev V, Handelsman DJ.   +10 more
europepmc   +1 more source

Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries. [PDF]

Science
Ling YH, Liang C, Wang S, Wu C.
europepmc   +1 more source