Results 241 to 250 of about 6,785,228 (313)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Potential of real-time pollen data: perceived needs and symptom management among seasonal allergic rhinitis patients. [PDF]

Front Allergy
van Gaal N, Boomsma C, Hall LF, van der Helm JJ.   +3 more
europepmc   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Plasma p-tau markers, vascular factors, and cognitive decline in the CIMA-Q cohort. [PDF]

Alzheimers Dement
Cottez RJ, Peyrot C, Denis HL, Tremblay C, Loiselle A, Dallaire-Théroux C, Filali-Mouhim A, Hébert SS, Leclerc N, Blennow K, Zetterberg H, Consortium for the Early Identification of Alzheimer's Disease – Quebec (CIMA‐Q), Kergoat MJ, Calon F, Pichet Binette A.   +14 more
europepmc   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

Factors Affecting Country Differences in the Incidence of Type 2 Diabetes Mellitus Based on the Global Burden of Disease Data 2021: A Multilevel Longitudinal Ecological Study. [PDF]

Health Sci Rep
Jaafari Z, Hassanzadeh J, Sayadi M, Sharifi MH, Mirahmadizadeh A.   +4 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Time to first sexual experience and its predictors among young women (15-24 years) in Zambia: Evidence from 2024 Demographic and Health Survey. [PDF]

PLOS Glob Public Health
Musonda E, Mumba P, Zulu R, Namayawa S, Sikaluzwe M, Bwalya BB, Phiri M.   +6 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Interrupted time series analysis of a digital nursing decision support system for postoperative lymphorrhea prevention in thyroid cancer: A single-center retrospective study. [PDF]

Medicine (Baltimore)
Du X, Duan M, Yang Y.
europepmc   +1 more source