Results 221 to 230 of about 9,112,332 (303)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Prior Out-of-Home Placement and Length of Stay Among Youths Receiving Mental Health Services in the ED.

JAMA Netw Open
Kelly CK, Saliba M, Park JH, Yoshii HK, Tarikogullari I, Tarasewicz A, Kaase A, Porter C, Boehm SM, Loy SN, LeMahieu A, Romanowicz M, Taylor-Desir MJ.   +12 more
europepmc   +1 more source

Subgroup analysis of genotype guided vs traditional warfarin dosing in Asian patients from an open label randomized trial. [PDF]

Sci Rep
Wong HJ, Teo YN, Teo YH, Syn NL, Wong AL, Teoh HL, Seet RCS, Lee SC, Goh BC, Sia CH.   +9 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Self-help group participation, avoidance of nonalcoholic beer, and nonsmoking independently predict better drinking outcomes in Japanese alcohol-dependent men. [PDF]

Alcohol Clin Exp Res (Hoboken)
Yokoyama A, Kimura M, Yoshimura A, Yoneda J, Maesato H, Komoto Y, Nakayama H, Sakuma H, Yumoto Y, Takimura T, Toyama T, Mizukami T, Yokoyama T, Higuchi S, Matsushita S.   +14 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Comparison of Urine pH in Postmenopausal Women With a Current, a History of, or No History of Uncomplicated Urinary Tract Infection. [PDF]

JU Open Plus
Zimmern P, Shah A, Alhalabi F, Christie A, Neugent M, Koonjbearry N, De Nisco N.   +6 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Analysis of Risk Prediction Model for Recurrence of Trigeminal Neuralgia After Percutaneous Balloon Compression. [PDF]

Pain Res Manag
Guo Y, Feng J, Ma Y, Zhang N, Gu J, Pei Z.   +5 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source