Results 171 to 180 of about 2,402,623 (312)

Jeffrey Mosher Interview

open access: yes, 2004
Mosher served in the United States Army from 1970 through 1973, during which time he achieved the rank of Specialist E4 and was a helicopter crew chief door gunner. Since 1990, he has been a Chief Petty Officer with the U.S. Navy Seabees.
Mosher, Jeffrey H.
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

John G. Miller Interview

open access: yes, 2004
Colonel Miller served in the U. S. Marines Corps from 1957-1985. During his career, he spent two tours in Vietnam, the first as a rifle company commander and battalion assistant operation officer, (S-3A) 1965-66, and the second time as a Co-van, an ...
Miller, John G.
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

KS2 history: exploring Tudor values

open access: yes, 2008
Expert in primary history Dr Hilary Cooper discusses a cross-curriculum approach to learning with Jen Ager, who recently applied the approach to teach about Tudor values.
Cooper, Hilary   +2 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

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