Results 61 to 70 of about 165,476 (262)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Relaxation time spectra of basaltic lavas between 500–1150 °C reveal patterns of Kramers–Kronig inconsistency of the complex viscoelastic shear modulus

open access: yesContributions to Geophysics and Geodesy, 2019
An important, yet until now neglected, aspect of the viscoelastic behaviour of lavas is the Kramers–Kronig consistency of their complex viscoelastic shear modulus.
Martin BEDNÁRIK, Igor KOHÚT
doaj   +1 more source

Fertility and Time Inconsistency [PDF]

open access: yesSSRN Electronic Journal, 2007
This paper analyzes the impact of (quasi-) hyperbolic discounting on timing and numbers of births. Using a simple three period model it shows that without the ability to save and borrow hyperbolic discounters postpone births and give birth to less children than previously intended. In the presence of a (perfect) capital market additional qualifications
openaire   +1 more source

Time-Inconsistent Bargaining and Cross-Commitments

open access: yesGames, 2023
The paper studies bargaining games involving players with present-biased preferences. The paper shows that the relative timing of bargaining rewards and bargaining costs will determine whether the players’ present-bias will affect bargaining outcomes. In cases where players agree to a bargain in period 1 and experience all bargaining payoffs in period ...
openaire   +4 more sources

Bailouts, Time Inconsistency, and Optimal Regulation [PDF]

open access: yesSSRN Electronic Journal, 2013
We develop a model in which, in order to provide managerial incentives, it is optimal to have costly bankruptcy. If benevolent governments can commit to their policies, it is optimal not to interfere with private contracts. Such policies are time inconsistent in the sense that, without commitment, governments have incentives to bail out firms by buying
V. V. Chari, Patrick J. Kehoe
openaire   +3 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

A feasibility study of establishing fiscal council in Indonesia

open access: yesEconomic Journal of Emerging Markets, 2018
In this paper we address the quantitative measurement of credibility in fiscal policy in the case of Indonesia over the period 2001-2016. This preliminary paper focuses on the deviations of the actual budget balances from the projections about these ...
Haryo Kuncoro
doaj   +3 more sources

Reliability and Availability Models of Belt Drive Systems Considering Failure Dependence

open access: yesChinese Journal of Mechanical Engineering, 2019
Conventional reliability models of belt drive systems in the failure mode of fatigue are mainly based on the static stress strength interference model and its extended models, which cannot consider dynamic factors in the operational duration and be used ...
Peng Gao, Liyang Xie, Jun Pan
doaj   +1 more source

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