Results 61 to 70 of about 17,407,057 (195)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Carrier drift modulation and hyperbolic time crystals

npj Metamaterials
We introduce carrier drift modulation—a new mechanism for creating temporal boundaries and enabling photonic time crystals. This approach opens a direct route to hyperbolic temporal metamaterials and, in particular, hyperbolic time crystals. We show that
Evgenii Narimanov, Boris Shapiro
doaj   +1 more source

A Generalized Spatial Modulation System Using Massive MIMO Space Time Coding Antenna Grouping

Entropy, 2020
Massive multiple input multiple output (MIMO), also known as a very large-scale MIMO, is an emerging technology in wireless communications that increases capacity compared to MIMO systems.
Amira I. Zaki, Mahmoud Nassar, Moustafa H. Aly, Waleed K. Badawi   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Time-resolved force microscopy using the delay-time modulation method

Applied Physics Express
We developed a time-resolved force microscopy technique by integrating atomic force microscopy using a tuning-fork-type cantilever with the delay time modulation method for optical pump-probe light.
Hiroyuki Mogi, Rin Wakabayashi, Shoji Yoshida, Yusuke Arashida, Atsushi Taninaka, Katsuya Iwaya, Takeshi Miura, Osamu Takeuchi, Hidemi Shigekawa   +8 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Optimum Mode-Switching-Assisted Constant-Power Single- and Multicarrier Adaptive Modulation

, 2003
A set of optimum mode-switching levels is derived for a generic constant-power adaptive-modulation scheme based on a closed-form expression of the average bit error ratio (BER) and the average bits-per-symbol (BPS) throughput of the adaptive-modulation ...
Choi, B.J., Hanzo, L.
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Transmitter Preprocessing Aided Spatial Modulation for Multiple-Input Multiple-Output Systems

, 2011
This paper proposes and studies a transmitter preprocessing aided spatial modulation (PSM) scheme, which conveys information jointly by a conventional amplitude-phase modulation (APM) and a preprocessing aided space shift keying (pre-SSK) modulation.
Yang, Lie-Liang
core   +2 more sources