Results 91 to 100 of about 22,582,174 (248)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Production Structure, Household Time Allocation, and Fertility [PDF]
This paper develops an overlapping generations model that incorporates two-sector (market and non-market) production, sexual difference, and fertility choice. Our model could explain the joint evolution of production structure, household time allocation,
Daishin Yasui, Masako Kimura
core
Deterministic economic production quantity models with time-varying demand and cost
, 2009 In today’s time-based competition, the unit cost of a high-tech product declines significantly over its short product life cycle. Consequently, in this paper, we relax the traditional economic production quantity model to allow for time-varying cost.
Teng, Jinn-Tsair; Ouyang, Liang-Yuh; Chang, Chun-tao
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Technical Production Showcase 2015 Photo Slideshow
, 2015 A short video containing Photos from the Launch of the Technical Production Showcase ...
QUT Technical Production
core +1 more source
Analyzing the postponement of time production systems in maketostock and seasonal demand [PDF]
, 2011 The supply chain management, postponement and demand management functions are of strategic importance to the economic success of organizations because they influence the production process, when viewed in isolation and empirically may hinder ...
Marins, Fernando Augusto Silva +5 more
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Consumption of working time in strawberry production
Agricultural and Food Science, 1981 The results of an empirical study of the working time consumed in strawberry production on Finnish farms are reviewed. Forty growers participated in the study, which took place between 1977—80.
Maritta Yläranta, Viljo Ryynänen
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source