Results 161 to 170 of about 22,430,852 (308)

Time Scale-Dependent Structure-Property Relationships in Dynamic Imine-Benzoxazine Networks. [PDF]

Macromolecules
Peyrefitte JJ, Hamernik LJ, Booker EM, Arrington JD, Wiggins JS.   +4 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Mechanistic Insights into Dioxygen Transport Routes in the PHD2 Oxygenase from Long-Time Scale Simulations. [PDF]

Biochemistry
Wiley B, Furini S, Domene C.
europepmc   +1 more source

Time-MoE: Billion-Scale Time Series Foundation Models with Mixture of Experts [PDF]

Deep learning for time series forecasting has seen significant advancements over the past decades. However, despite the success of large-scale pre-training in language and vision domains, pre-trained time series models remain limited in scale and operate
Shiyu, Wang, Zhou, Ye, Jin, Ming, Qingsong, Wen, Dianqi, Li, Xiaoming, Shi, Yuqi, Nie   +6 more
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Predicting Critical Micelle Concentrations from Short Time Scale Simulations. [PDF]

J Phys Chem B
Rummel F, Robinson JF, Warren PB, Bray DJ, Anderson RL.   +4 more
europepmc   +1 more source

Microbial methane cycling in a landfill on a decadal time scale. [PDF]

Nat Commun, 2023
Grégoire DS, George NA, Hug LA.
europepmc   +1 more source

Time-Life Books, eds. The studio

, 1976
Life lib of photography236 p.; 25 ...
Time-life Int.
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Test of the reward/circadian rhythm dysregulation model of risk for bipolar spectrum disorders at a micro time scale using multilevel moderated mediation. [PDF]

J Psychopathol Clin Sci
Smith LT, Maddox MA, Walsh RFL, Klugman J, Goel N, Alloy LB.   +5 more
europepmc   +1 more source