Results 191 to 200 of about 11,420,922 (288)

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Time Scale Network: An Efficient Shallow Neural Network For Time Series Data in Biomedical Applications. [PDF]

IEEE J Sel Top Signal Process
Meyer T, Shultz C, Dehak N, Moro-Velázquez L, Irazoqui P.   +4 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Dynamic connectivities of plant metacommunities at a millennial time-scale: the Beringia testbed

Herzschuh U, Stoof-Leichsenring KR, Farkas LZ, Liu Y, Liu S, Böhmer T, Baisheva I, Biskaborn BK, Courtin J, Diekmann B, Epp LS, von Hippel B, Huang S, Huang Y, Jia W, Kaufman DS, Meyer H, Melles M, Meucci S, Pestryakova LA, Schulte L, Wagner B, Wang Z, Zakharov ES.   +23 more
europepmc   +1 more source

Long-Time Scale Simulations Reveal Key Dynamics That Drive the Onset of the N State in the Proteorhodopsin Photocycle. [PDF]

J Phys Chem B
Billings KR, Faramarzi S, Mertz B.
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Partial asynchrony of coniferous forest carbon sources and sinks at the intra-annual time scale. [PDF]

Nat Commun
Silvestro R, Mencuccini M, García-Valdés R, Antonucci S, Arzac A, Biondi F, Buttò V, Camarero JJ, Campelo F, Cochard H, Čufar K, Cuny HE, de Luis M, Deslauriers A, Drolet G, Fonti MV, Fonti P, Giovannelli A, Gričar J, Gruber A, Gryc V, Guerrieri R, Güney A, Guo X, Huang JG, Jyske T, Kašpar J, Kirdyanov AV, Klein T, Lemay A, Li X, Liang E, Lintunen A, Liu F, Lombardi F, Ma Q, Mäkinen H, Malik RA, Martinez Del Castillo E, Martinez-Vilalta J, Mayr S, Morin H, Nabais C, Nöjd P, Oberhuber W, Olano JM, Ouimette AP, Paljakka TVS, Peltoniemi M, Peters RL, Ren P, Prislan P, Rathgeber CBK, Sala A, Saracino A, Saulino L, Schiestl-Aalto P, Shishov VV, Stokes A, Sukumar R, Sylvain JD, Tognetti R, Treml V, Urban J, Vavrčík H, Vieira J, von Arx G, Wang Y, Yang B, Zeng Q, Zhang S, Ziaco E, Rossi S.   +72 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Atomistic Mechanism of Lipid Membrane Binding for Blood Coagulation Factor VIII with Molecular Dynamics Simulations on a Microsecond Time Scale. [PDF]

J Phys Chem B
Avery NG, Childers KC, McCarty J, Spiegel PC.   +3 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source