Results 31 to 40 of about 805,121 (258)

Lacunary statistical boundedness on time scales

open access: yesAdvances in Difference Equations, 2021
In this paper, we introduce the concept of lacunary statistical boundedness of Δ-measurable real-valued functions on an arbitrary time scale. We also give the relations between statistical boundedness and lacunary statistical boundedness on time scales.
Bayram Sözbir, Selma Altundağ
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

The Lie Brackets on Time Scales

open access: yesAbstract and Applied Analysis, 2012
The Lie derivative, which has a wide range of application in physics and geometry, is trying to be examined on time scales. Firstly, nabla Lie bracket is defined on two-dimensional time scales.
H. Kusak, A. Caliskan
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Some new dynamic Gronwall–Bellman–Pachpatte type inequalities with delay on time scales and certain applications

open access: yesJournal of Inequalities and Applications, 2022
The main objective of the present article is to prove some new delay nonlinear dynamic inequalities of Gronwall–Bellman–Pachpatte type on time scales. We introduce very important generalized results with the help of Leibniz integral rule on time scales ...
Ahmed A. El-Deeb, Dumitru Baleanu
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Parameter-Dependent Dirac Systems on Time Scales

open access: yesCumhuriyet Science Journal, 2018
In this study, we consider two generalized Dirac systems on a time scaleand a boundary-value problem with boundary conditions depending on the spectralparameter. We give some sufficient conditions for disconjugacy of the systemsand obtain a formula about
Ahmet Sinan Özkan
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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