Results 121 to 130 of about 338,638 (289)
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Using bundle embeddings to predict daily cortisol levels in human subjects
BMC Medical Research Methodology, 2018 Background Many biological variables sampled from human subjects show a diurnal pattern, which poses special demands on the techniques used to analyze such data. Furthermore, most biological variables belong to nonlinear dynamical systems, which may make
Roelof B. Toonen +4 more
doaj +1 more source
A Geometric Renormalisation Group in Discrete Quantum Space-Time
, 2002 We model quantum space-time on the Planck scale as dynamical networks of elementary relations or time dependent random graphs, the time dependence being an effect of the underlying dynamical network laws.
Requardt, Manfred
core +3 more sources
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
PLoS Computational BiologyAbrupt changes in system states and dynamical behaviors are often observed in natural systems; such phenomena, named regime shifts, are explained as transitions between alternative steady states (more generally, attractors).
Yong-Jin Huang +2 more
doaj +1 more source
Microscopic chaos and diffusion
, 2000 We investigate the connections between microscopic chaos, defined on a dynamical level and arising from collisions between molecules, and diffusion, characterized by a mean square displacement proportional to the time. We use a number of models involving
Cohen, E. G. D., Dettmann, C. P.
core
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Ultralow‐Dimensionality Reduction for Identifying Critical Transitions by Spatial‐Temporal PCA
Advanced ScienceDiscovering dominant patterns and exploring dynamic behaviors especially critical state transitions and tipping points in high‐dimensional time‐series data are challenging tasks in study of real‐world complex systems, which demand interpretable data ...
Pei Chen +6 more
doaj +1 more source
Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Modelûvannâ, 2016 For the wide class of 3D autonomous quadratic dynamical systems depending on parameters the sucient conditions of boundedness of solutions of any system from this class are found. A connection between change of one of the parameters and a recurrence plot structure, which was built on the time series for any system of this class, is determined.
V. Ye. Belozyorov, V. G. Zaytsev
openaire +1 more source