Results 71 to 80 of about 227,005 (260)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Unraveling Meteorological Dynamics: A Two-Level Clustering Algorithm for Time Series Pattern Recognition with Missing Data Handling

Stats
Identifying regions with similar meteorological features is of both socioeconomic and ecological importance. Towards that direction, useful information can be drawn from meteorological stations, and spread in a broader area.
Ekaterini Skamnia, Eleni S. Bekri, Polychronis Economou   +2 more
doaj   +1 more source

Time series similarity measurement based on fractionaldifferential and its application

四川大学学报. 自然科学版, 2023
Similarity measures of time series are the basis for time series clustering, classification and other related time series analysis. The traditional distance-based similarity measure ignores the possible temporal connections of time series and treats time
YAN Wen-Peng, WANG Zhi-Tao, YUAN Xiao
doaj  

Similarity dynamical clustering algorithm based on multidimensional shape features for time series

工程科学学报, 2017
Traditional data mining methods are difficult to deal with the high dimensionality and dynamics characteristic of the time series. Therefore, in this study, a similarity dynamical clustering algorithm based on multidimensional shape features for time ...
WANG Ling, MENG Jian-yao, XU Pei-pei, PENG Kai-xiang   +3 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Exploring Optimal Strategies for Small Hydro Power Forecasting: Training Periods and Methodological Variations

Engineering Proceedings
This study investigates optimal training intervals for small hydro power regression models, crucial for accurate forecasts in diverse conditions, particularly focusing on Portugal’s small hydro portfolio.
Duarte Lopes, Isabel Preto, David Freire
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

ESTIMATE OF TIME SERIES SIMILARITY BASED ON MODELS

Міжнародний науково-технічний журнал "Проблеми керування та інформатики"
Determining the measure of the distance between time series is the starting point for many data mining tasks such as clustering and classification. Clustering is the main method of teaching without a teacher, which is used to divide data into groups ...
Т.В. Кнігніцька
doaj   +1 more source