Results 81 to 90 of about 174,276,385 (305)

Stochastic modelling of the spatial spread of influenza in Germany [PDF]

, 2005
In geographical epidemiology, disease counts are typically available in discrete spatial units and at discrete time-points. For example, surveillance data on infectious diseases usually consists of weekly counts of new infections in pre-defined ...
Dargatz, C, Held, Leonhard, Georgescu, Vera, Georgescu, V, Held, L, Dargatz, Christiane ; https://orcid.org/, Dargatz, Christiane, Christiane Dargatz, Leonhard Held, Vera Georgescu   +9 more
core   +2 more sources

Global Heated Tobacco Product User Estimates, 2014-2024: Descriptive Surveillance Study Using Manufacturer Disclosures

JMIR Public Health and Surveillance
BackgroundHeated tobacco products (HTPs) expanded rapidly after 2014; yet globally, comparable estimates of the number of HTP users remain limited. National surveys rarely include standardized HTP measures, and international surveillance systems do not ...
Giorgi Mzhavanadze, Gerry V Stimson, Tomasz Jerzyński   +2 more
doaj   +1 more source

Explaining offenders’ longitudinal product-specific target selection through changes in disposability, availability, and value: an open-source intelligence web-scraping approach

Crime Science, 2022
Objective To address the gap in the literature and using a novel open-source intelligence web-scraping approach, this paper investigates the longitudinal relationships between availability, value, and disposability, and stealing counts of specific makes ...
Liam Quinn, Joseph Clare, Jade Lindley, Frank Morgan   +3 more
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

A Time Series Analysis of Monthly Fire Counts in Ontario, Canada, with Consideration of Climate Teleconnections

Fire
Climate change can impact various facets of a region’s fire regime, such as the frequency and timing of fire ignitions. This study examines the temporal trends of monthly fire counts in the Northwest and Northeast Regions of Ontario, Canada, between 1960
Emmanuella Boateng, Kevin Granville
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A two-component model for counts of infectious diseases [PDF]

, 2005
We propose a stochastic model for the analysis of time series of disease counts as collected in typical surveillance systems on notifiable infectious diseases.
Schmid, V, Held, Leonhard, Höhle, Michael, Held, L, Hofmann, M., Hofmann, Mathias, Höhle, M, Schmid, Volker J., Schmid, Volker, Hofmann, M   +9 more
core   +1 more source

Sunspot number recalibration: The ~1840–1920 anomaly in the observer normalization factors of the group sunspot number

Journal of Space Weather and Space Climate, 2017
We analyze the normalization factors (k′-factors) used to scale secondary observers to the Royal Greenwich Observatory (RGO) reference series of the Hoyt & Schatten (1998a, 1998b) group sunspot number (GSN).
Cliver Edward W.
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source