Results 201 to 210 of about 192,349 (314)

pH‐Controlled Gliding Motions in Pillar[5]arene‐Containing Molecular Shuttles

open access: yesChemistryEurope, EarlyView.
The perfectly reversible protonation/deprotonation of pillar[5]arene‐based molecular shuttles allows to control the amplitude of the gliding motions of the macrocyclic component along the axle moiety. Such motions occur over the full length of the molecular axle in the protonated state.
Nihed Becharguia   +6 more
wiley   +1 more source

Dynamic Combinatorial Chemistry of Ditellurides

open access: yesChemistry – A European Journal, EarlyView.
Ditelluride exchange. Chemically and structurally diverse ditellurides undergo a rapid Te‐Te exchange under mild reaction conditions in the absence of an external stimulus, indicating that ditellurides could find application in various dynamic molecular systems.
Christian D. Fisker   +3 more
wiley   +1 more source

Disruption of salt bridge interactions in the inter‐domain cleft of the tubulin‐like protein FtsZ of Escherichia coli makes cells sensitive to the cell division inhibitor PC190723

open access: yesCytoskeleton, EarlyView.
Abstract FtsZ forms a ring‐like assembly at the site of division in bacteria. It is the first protein involved in the formation of the divisome complex to split the cell into two halves, indicating its importance in bacterial cell division. FtsZ is an attractive target for developing new anti‐microbial drugs to overcome the challenges of antibiotic ...
Sakshi Mahesh Poddar   +3 more
wiley   +1 more source

Synthesis, Antimycobacterial Activity and Computational Insight of novel 1,4‐Benzoxazin‐2‐one Derivatives as Promising Candidates Against Multidrug‐Resistant M. tuberculosis

open access: yesChemMedChem, Accepted Article.
To search for new antitubercular agents, we have designed, synthesized, and evaluated a series of 1,4‐benzoxazinone‐based compounds. These molecules showed potent antimycobacterial activity, with MIC between 2 and 8 μg/mL. This interesting profile included activity against several drug‐resistant strains and minimal cytotoxicity against mammalian Vero ...
Daniele Zampieri   +6 more
wiley   +1 more source

Is Mycobacterial InhA a Suitable Target for Rational Drug Design?

open access: yesChemMedChem, EarlyView.
InhA is the target of isoniazid, a first‐line antituberculosis drug. Isoniazid is, in fact, a prodrug that needs to be activated. Researchers are trying to develop direct inhibitors of InhA. This includes the resolution of crystallographic structures. The Protein Data Bank contains over a hundred InhA structures.
Julien Rizet   +7 more
wiley   +1 more source

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