Results 211 to 220 of about 503,602 (261)
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia +9 more
wiley +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
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2022
Mental time travel research has given rise to an ongoing debate between causal and simulation theories of memory, which has, in turn, triggered a debate between continuist and discontinuist views of the relationship between remembering experienced past events and imagining possible future events.
Perrin, Denis +3 more
openaire +3 more sources
Mental time travel research has given rise to an ongoing debate between causal and simulation theories of memory, which has, in turn, triggered a debate between continuist and discontinuist views of the relationship between remembering experienced past events and imagining possible future events.
Perrin, Denis +3 more
openaire +3 more sources
Acta Mathematica Sinica, English Series, 2019
This paper is a survey of some results on travel time tomography. If the anisotropic index of refraction of a medium can be determined by measuring the travel times of waves going through the medium can be recast as geometry problems whose linearization versions lead to tensor tomography. The question is whether one can determine a symmetric two-tensor
Stefanov, Plamen D. +3 more
openaire +3 more sources
This paper is a survey of some results on travel time tomography. If the anisotropic index of refraction of a medium can be determined by measuring the travel times of waves going through the medium can be recast as geometry problems whose linearization versions lead to tensor tomography. The question is whether one can determine a symmetric two-tensor
Stefanov, Plamen D. +3 more
openaire +3 more sources
On Travelling Backward in Time
Synthese, 1972In his recent article ‘It Ain’t Necessarily So’, Hilary Putnam (1962, p. 668) remarks that “in the last few years I have been amused and irritated by the spate of articles proving that time travel is a ‘conceptual impossibility’.”
openaire +1 more source
The Caracol Time Travel Project
The Journal of Visualization and Computer Animation, 2001AbstractVirtual drama is based on the use of a shareable virtual world as a stage setting, with avatars controlled by actors and audience members. The Caracol Time Travel Project was an experiment in the use of virtual drama for learning about archaeology.
Charles E. Hughes +4 more
openaire +3 more sources