Results 81 to 90 of about 52,263 (269)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
The Relation between Changes in Audit Opinion and Financial Reporting Delay [PDF]
مطالعات تجربی حسابداری مالی, 2013 Timeliness is an important qualitative characteristic of financial information. The timeliness of information means that information should be provided to users in the shortest time and the fast way possible.
Zahra Hajiha, Mojtaba Fathi Moghadam
doaj
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Analysis and improvement of ZG off-line TTP non-repudiation protocol
Tongxin xuebao, 2009 Based on the weakness of ZG off-line TTP（trusted third party） non-repudiation protocol because of using pro-tocol deadline, the improvement of the ZG off-line TTP non-repudiation protocol was given, which eliminated the delay-ing resolve request attack ...
LIU Dong-mei1 +3 more
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TIMELINESS ASSESSMENT FOR IMPLEMENTATION OF THE CRITICAL REQUESTS IN TWO-LEVEL CLUSTERS [PDF]
Научно-технический вестник информационных технологий, механики и оптики, 2014 The paper deals with probability evaluation for timely service of requests in real-time systems at the time less than permitted limit in a two-level cluster where each incoming request is served first, in one of the bottom-level nodes and then in one of ...
A. V. Bogatyrev +2 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Timeliness analysis on organization intervention of miners’ unsafe behavior
矿业科学学报, 2016 In order to investigate the effect and the timeliness of the organization intervention of miners’ unsafe behavior, the organizational intervention system which covers the entire coal mine system was constructed combining with the actual coal mine.The ...
Tong Ruipeng, Chen Ce, Liu Dapeng
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