Results 181 to 190 of about 602,512 (257)

Multimodal MRI and multiomics reveal high‐risk neurophenotype in brain‐gut circuits as therapeutic target for Crohn's disease

open access: yesInterdisciplinary Medicine, EarlyView.
Through a translational framework combining prospective dual‐center clinical cohorts with dextran sulfate sodium‐induced colitis models, this work integrated advanced neuroimaging, multi‐omics and neuromodulation interventions to redefine the high‐risk neurophenotype as a sustained pathogenic driver rather than a mere phenomenon, proposing brain‐gut ...
Xuehua Li   +24 more
wiley   +1 more source

‘Pre‐Technologies’ and the Lifeworld: Assistive Technologies as ‘Pre‐Technologies’ for Self‐Formation as Freedom

open access: yesJournal of Applied Philosophy, EarlyView.
ABSTRACT This article identifies assistive technologies (ATs) as ‘pre‐technologies’ mediating access to other technologies for disabled subjects (DSs). The motivation is to show that without ATs, DSs cannot be said to have the same level of access to freedom and self‐forming activities as able‐bodied subjects.
Sarel Marais
wiley   +1 more source

Immunomodulatory and Cytotoxic Properties of Enniatin B1 in Porcine Alveolar Macrophages

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT This study investigates the immunomodulatory effects of Enniatin B1 (ENNB1), an emerging mycotoxin, on porcine alveolar macrophages (PAMs), a species‐specific model relevant to human innate immunity. PAMs were exposed to increasing ENNB1 concentrations (0.5–6 μM) over 6, 24, and 48 h.
Sara Frazzini   +4 more
wiley   +1 more source

Subchronic Exposure to Arsenic and Nickel Triggers Nitrosative Stress and Histological Alterations in the Rat Liver

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Environmental exposure to heavy metals poses a threat to human health. Several studies documented harmful effects on the liver after arsenic and nickel exposure at concentrations beyond permissible limits. Nevertheless, the impact of a simultaneous exposure to both elements on hepatic biochemistry and histology remains unelucidated. Therefore,
Thainá Iasbik‐Lima   +4 more
wiley   +1 more source

Tannic Acid Mitigates Monosodium Glutamate‐Induced Cortical Damage by Modulating Synaptic and Calcium‐Related Gene and Protein Expression

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Neurotoxicity induced by excessive glutamatergic signaling is associated with synaptic dysfunction, calcium imbalance, and oxidative stress, which are key molecular events implicated in several neurodegenerative conditions. Monosodium glutamate (MSG), a common flavor enhancer, may exert neurotoxic effects, particularly on synaptic integrity ...
Medine Sibel Karagac   +2 more
wiley   +1 more source

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