Results 161 to 170 of about 166,659,543 (300)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The school–community interface during times of crisis: Mediating and remediating a ‘youth crime crisis’

This chapter examines the role and positioning of the school as predominant social institution integral to the lives and experiences of young people. As an institution responsible for socialising young people and providing aspirations toward lifeways ...
Riddle, Stewart, Hickey, Andrew, Orchard, Hannah, McCarthy, Michelle   +3 more
core   +1 more source

One Health approach to mental health- mental health recovery in times of crisis: conference proceeding. [PDF]

BMC Proc
Megersa SW, Balcha YT, Abdullahi MA, Krahl W, Krahl N, Jebrini T, Mahr-Slotawa J, Jobst A.   +7 more
europepmc   +1 more source

Toxic Absence: Why Leader Presence Matters in Times of Crisis. [PDF]

J Nurs Manag, 2023
McMurray R, Credland N, Griffin M, Hamilton P, Harness O.   +4 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Literature review on provision of appropriate and accessible support to people with an intellectual disability who are experiencing crisis pregnancy

, 2011
The Crisis Pregnancy Agency [2] and the National Disability Authority commissioned this systematic review of Irish and international literature to identify international models of good practice regarding crisis pregnancy counselling and support ...
O'Connor, Joan
core  

Implementing a professional youth mentoring program during times of crisis: lessons from the global pandemic. [PDF]

Int J Adolesc Youth
Hanson KG, Satchell AK, Skinner ML, Eddy JM.   +3 more
europepmc   +1 more source

Enhanced Vulnerability of Asylum Seekers in Times of Crisis. [PDF]

Hum Rights Rev, 2023
Phillips S.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Hematology in times of crisis: Lessons learned and strategic priorities from the EHA-ASH Joint Workshop on Ukraine. [PDF]

Hemasphere
Istomin O, Yakimkova T, Belkhedim R, Bolaños N, Döhner K, Ganser A, Haferlach T, Ilbawi A, Kacharian A, Kizyma R, Klymenko S, Korenkova S, Leebeek F, Lysytsia O, Medvediev B, Mlynarski W, Niederwieser D, Nogovitsyna Y, Rondelli D, Selina I, Usenko G, Shokun N, Heyman M, Niemeyer C, Müller A.   +24 more
europepmc   +1 more source