Results 31 to 40 of about 79,204 (264)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
A Paleoarchaean impact crater in the Pilbara Craton, Western Australia
Nature CommunicationsThe role of meteorite impacts in the origin, modification, and destruction of crust during the first two billion years of Earth history (4.5–2.5 billion years ago; Ga) is disputed.
Christopher L. Kirkland +6 more
doaj +1 more source
Anticipation of temporally structured events in the brain
eLife, 2021 Learning about temporal structure is adaptive because it enables the generation of expectations. We examined how the brain uses experience in structured environments to anticipate upcoming events.
Caroline S Lee +2 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
A general(ized) local rheology for wet granular materials
New Journal of Physics, 2017 We study the rheology of dry and wet granular materials in the steady quasistatic regime using the discrete element method in a split-bottom ring shear cell with focus on the macroscopic friction.
Sudeshna Roy +2 more
doaj +1 more source
Exploiting Multiple Timescales in Hierarchical Echo State Networks
Frontiers in Applied Mathematics and Statistics, 2021 Echo state networks (ESNs) are a powerful form of reservoir computing that only require training of linear output weights while the internal reservoir is formed of fixed randomly connected neurons. With a correctly scaled connectivity matrix, the neurons’
Luca Manneschi +6 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
A Design-Oriented Analysis of Multimodality in English as a Foreign Language
Designs for Learning, 2018 This empirical article investigates multimodality in English as a foreign language, both as seen in the use of multimodal texts as artefacts and pedagogical texts for learning, and through an analysis of the multimodal learning designs.
Ingrid Karoline Jakobsen +1 more
doaj +1 more source
From Frequency Content to Signal Dynamics Using DNNs
IEEE Access, 2022 This study developed a novel method for analyzing and decomposing a signal into its main dynamics for small and large timescales. Our proposal is based on a decoupled hybrid system of convolutional and recurrent neural networks that uses as inputs the ...
Javier De Pedro-Carracedo +3 more
doaj +1 more source
Timescales of Massive Human Entrainment
PLOS ONE, 2015 20 pages, 7 figures, 6 tables, 4 supplementary figures. 2nd version revised according to peer reviewers' comments: more detailed explanation of the methods, and grounding of the ...
Fusaroli, Riccardo; id_orcid 0000-0003-4775-5219 +5 more
openaire +8 more sources