Results 71 to 80 of about 1,609 (213)

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Effects of Tip Cavity Depth, Width, and Location on the Leakage Flow in an Axial Turbine Cascade

Journal of Fluid Science and Technology, 2010
In this study, effects of the tip cavity with various depths, widths, and locations on the leakage flow and performance of an axial turbine cascade have been investigated numerically.
Mohamed EL-GHANDOUR, Mohammed K. IBRAHIM, Katsunori DOI, Yoshiaki NAKAMURA   +3 more
doaj   +1 more source

Influence factors and prediction model of enstrophy dissipation from the tip leakage vortex in a multiphase pump. [PDF]

Sci Rep, 2022
Shu Z, Shi G, Yao X, Sun G, Tao S.
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Groundwater Rise Sustains the World's Largest Alpine Water System Under Global Warming

Advanced Science, EarlyView.
Shallow groundwater depth (SGWD) across the non‐permafrost plains of the Qinghai–Xizang Plateau decreased at averagely 0.02 m year−1, adding 31.44 Gt of freshwater storage from 2000 to 2020 and sustaining ∼53 500 km2 of alpine ecosystems. A vadose‐zone capacity of 426.6 Gt reveals these aquifers as promising reservoirs, highlighting groundwater's ...
Jianqing Du, Zhixiang Niu, Yanfen Wang, Shirui Zhou, Youqing Yang, Xiang Wei, Haishan Niu, Yitao Zhang, Anquan Xia, Yali Liu, Yanbin Hao, Kai Xue, Bingfang Wu, Xinquan Zhao, Tandong Yao, Yiyu Chen   +15 more
wiley   +1 more source

Analysis of Different POD Processing Methods for SPIV-Measurements in Compressor Cascade Tip Leakage Flow

Energies, 2019
Though the proper orthogonal decomposition (POD) method has been widely adopted in flow analysis, few publications have systematically studied the influence of different POD processing methods on the POD results.
Lei Shi, Hongwei Ma, Lixiang Wang
doaj   +1 more source

Scan‐Path‐ and Initial‐State‐Dependent Superdomain Switching in (111)‐Oriented PZT

Advanced Electronic Materials, EarlyView.
Scan trajectory and initial superdomain topology govern polarization switching in (111)‐oriented PZT. Automated AFM writing, pulsing experiments, and interferometric 3D‐PFM show that raster scans reproducibly stabilize ordered Type‐I stripe superdomains with constrained variant selection, whereas spiral trajectories generate frustrated mixed‐variant ...
Rama Vasudevan, Laveeza Ahmad, Bharat Pant, Ralph Bulanadi, Asraful Haque, Puneet Kaur, Sabine Neumayer, Jan‐Chi Yang, Yongtao Liu, Ye Cao, Stephen Jesse, Marti Checa   +11 more
wiley   +1 more source

Effects of cutback squealer tips on the vortices and local loss in the tip region of axial turbine rotor

Propulsion and Energy
Tip leakage loss is a significant source of aerodynamic loss in the turbine rotor and can be controlled by using a cavity tip. In this paper, three configurations with cutback rims are numerically investigated to control the formation and development of ...
Weihao Zhang, Yufan Wang, Kailai Chen, Dongming Huang   +3 more
doaj   +1 more source

Influence of the Tip Clearance on the Aeroelastic Characteristics of a Last Stage Steam Turbine

Applied Sciences, 2019
In this paper, the tip clearance effects on the aeroelastic stability of a last-stage steam turbine model are investigated. Most of the unsteady aerodynamic work contributing to flutter of the long blades of the last-stage of a steam turbine is done near
Tianrui Sun, Anping Hou, Mingming Zhang, Paul Petrie-Repar   +3 more
doaj   +1 more source

Real‐Time Multicolor Fluorescence Microscopy via Cross‐Channel Acquisition and Deep‐Learning‐Based Inference

Advanced Intelligent Discovery, EarlyView.
Sequential multicolor fluorescence imaging in dynamic microsystems is constrained by acquisition speed and excitation dose. This study introduces a real‐time framework to reconstruct spectrally separated channels from reduced cross‐channel acquisitions (frames containing mixed spectral contributions).
Juan J. Huaroto, Yuxin Jin, Nicholas Roy, Sarthak Misra   +3 more
wiley   +1 more source