Results 161 to 170 of about 6,300 (191)
Safety, efficacy and timing of antithrombotic therapy in emergency stenting of acute stroke patients with tandem lesions, German multicenter data-analysis. [PDF]
Keil F+14 more
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Safety evaluation of tirofiban
Expert Opinion on Drug Safety, 2010Heightened platelet activity is pivotal in the thrombosis underlying acute coronary syndrome (ACS). The glycoprotein IIb/IIIa inhibitor tirofiban is a powerful platelet inhibitor with demonstrated efficacy and safety across the spectrum of ACS. Despite tirofiban's impact on the platelet compared with placebo, only an excess in minor and importantly not
Marco Valgimigli, Matteo Tebaldi
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Risedronate Sodium and Tirofiban Hydrochloride [PDF]
Each month, subscribers to The Formulary® receive print and electronic versions of at least six monographs reviewing new drug entities or related drugs within a category. Some reviews take a second look at currently available drugs, whereas other preliminarily evaluate agents about to be released—just in time for use with your Pharmacy and ...
Danial E. Baker, Terri Levien
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Tirofiban for myocardial infarction
Expert Opinion on Pharmacotherapy, 2010Inhibition of platelet aggregation plays a key role in treatment of coronary artery disease.Studies on the effects of tirofiban in patients with either ST elevation or non-ST elevation myocardial infarction are reviewed.Tirofiban is a small-molecule glycoprotein IIb/IIIa receptor inhibitor. If discontinued, the action of tirofiban is faster reversed as
Harry Suryapranata+3 more
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Tirofiban-associated acute thrombocytopenia
Acta Cardiologica, 2006Randomized clinical trials of glycoprotein IIb/IIIa inhibition during percutaneous coronary intervention have shown significant clinical efficacy and safety in reducing the morbidity and mortality. In Turkey, only tirofiban is available. Tirofiban is a safe and effective agent in combination with heparin and aspirin in the setting of an acute coronary ...
Tuhta, Aylin G.+2 more
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Tirofiban for the treatment of ischaemic stroke
Expert Opinion on Pharmacotherapy, 2005Tirofiban is one of three glycoprotein IIb/IIIa receptor antagonists approved by the US FDA, beside abciximab and eptifibatide. The approval of tirofiban covers conservative treatment of myocardial infarction and unstable angina, as well as percutaneous coronary intervention, for which treatment with tirofiban is recommended in moderate-to-high-risk ...
Michael Daffertshofer+2 more
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Tirofiban in acute coronary syndromes
Expert Review of Cardiovascular Therapy, 2005Acute coronary syndromes represent a major health problem in terms of incidence and mortality. Intracoronary platelet-rich thrombi may develop in response to plaque rupture, and are involved in the pathogenesis of all acute coronary syndromes. The glycoprotein IIb/IIIa receptor, a platelet surface integrin, plays a key role in platelet aggregation once
Alberto Menozzi+2 more
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Safety and efficacy of Tirofiban in STEMI-patients
International Journal of Cardiology, 2019Tirofiban is recommended as bail out therapy in patients with ST-elevation myocardial infarction (STEMI). However, evidence regarding safety and efficacy of tirofiban is unclear. Tirofiban has been shown to improve ST-resolution, to decrease infarct size (IS) and to reduce incidence of major adverse cardiac and cerebrovascular events (MACCE).
Dannenberg, Lisa+12 more
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In Vitro and In Vivo Studies on the Metabolism of Tirofiban
Drug Metabolism and Disposition, 1999Tirofiban hydrochloride [L-tyrosine-N-(butylsulfonyl)-O-[4-(4-piperidinebutyl)] monohydrochloride, is a potent and specific fibrinogen receptor antagonist. Radiolabeled tirofiban was synthesized with either (3)H-label incorporated into the phenyl ring of the tyrosinyl residue or (14)C-label in the butane sulfonyl moiety.
S, Vickers+12 more
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