Results 181 to 190 of about 12,434,864 (335)

Cross-tissue organization of the fibroblast lineage

Nature, 2021
M. Buechler, R. Pradhan, Akshay T. Krishnamurty, Christian B. Cox, Aslihan Karabacak Calviello, Amber W Wang, Y. Yang, Lucinda Tam, R. Caothien, Merone Roose-Girma, Z. Modrusan, J. Arron, R. Bourgon, Sören Müller, S. Turley   +14 more
semanticscholar   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Influence of Electrode-Tissue Contact Area on Parameter Sensitivity in Electrosurgical Monopolar Soft Coagulation: A Multiphysics Finite Element Study. [PDF]

Sensors (Basel)
Busch C, Rupitsch SJ, Moeller K.
europepmc   +1 more source

Tissue Cells Feel and Respond to the Stiffness of Their Substrate

Science, 2005
D. Discher, P. Janmey, Yu-li Wang
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Transcriptional regulation in skeletal muscle and adipose tissue of lean and obese colony cats. [PDF]

PLoS One
Rigotti R, Liesegang A, Dawson H, Brugger D, Frey D, Samaha G, Haase B, Wichert B.   +7 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Physiologically Relevant Organotypic Tissue Slice Model for Evaluating Cell Responses to Ionizing Radiation. [PDF]

Int J Mol Sci
Shestakova V, Smirnova E, Isaeva E, Smirnova A, Atiakshin D, Yatsenko E, Yakimova A, Koryakin S, Baranovskii D, Saburov V, Sulina Y, Komarova L, Ivanov S, Shegay P, Kaprin A, Klabukov I.   +15 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Time-dependent integrated tissue and circulating biomarker dynamics of spexin and progranulin in an experimental myocardial infarction model. [PDF]

Histochem Cell Biol
Kaya S, Yalçin T.
europepmc   +1 more source