Results 1 to 10 of about 437,688 (231)

New therapeutic approaches of mesenchymal stem cells-derived exosomes

Journal of Biomedical Science, 2021
Mesenchymal stem cells (MSCs) have been demonstrated to have a great potential in the treatment of several diseases due to their differentiation and immunomodulatory capabilities and their ability to be easily cultured and manipulated.
Jana Janockova, Lucia Slovinska, Denisa Harvanova, Timea Spakova, Jan Rosocha   +4 more
doaj   +1 more source

Bone marrow aspirate concentrate/platelet-rich fibrin augmentation accelerates healing of aseptic upper limb nonunions

Journal of Orthopaedics and Traumatology, 2021
Introduction Nonunions remain a significant burden in orthopedics, often afflicting young males of working age. Positive findings have been published using bone marrow aspirate concentrate (BMAC) and platelet-rich fibrin (PRF) for the treatment ...
Alessandro Mazzotta, Cesare Stagni, Martina Rocchi, Nicola Rani, Nicolandrea Del Piccolo, Giuseppe Filardo, Dante Dallari   +6 more
doaj   +1 more source

Randomised, double-blind comparison of a fixed co-formulation of intra-articular polynucleotides and hyaluronic acid versus hyaluronic acid alone in the treatment of knee osteoarthritis: two-year follow-up

BMC Musculoskeletal Disorders, 2021
Background A first-year interim analysis of this two-year study suggested that intra-articular injections of highly purified, natural-origin polynucleotides and hyaluronic acid (HA) as a fixed combination (PNHA) might improve knee function and joint pain
Cesare Stagni, Martina Rocchi, Alessandro Mazzotta, Nicolandrea Del Piccolo, Nicola Rani, Marco Govoni, Leonardo Vivarelli, Francesca Veronesi, Milena Fini, Dante Dallari   +9 more
doaj   +1 more source

Plasma-derived extracellular vesicle surface markers CD45, CD326 and CD56 correlate with the stage of osteoarthritis: a primary study of a novel and promising diagnostic tool of the disease

Scientific Reports, 2023
Recently, there is a growing interest in the research based on extracellular vesicles (EVs) which represent paracrine factors secreted by almost all cell types.
Jana Matejova, Livia K. Fecskeova, Lucia Slovinska, Denisa Harvanova, Timea Spakova, Jana Bzdilova   +5 more
doaj   +1 more source

A Comparative Study Using Fluorescent Confocal Microscopy and Flow Cytometry to Evaluate Chondrocyte Viability in Human Osteochondral Allografts

Bioengineering, 2022
The preservation conditions of fresh osteochondral allografts for clinical applications are critical due their objective: to transplant mature hyaline cartilage containing viable chondrocytes, maintaining their metabolic activity and also preserving the ...
Patricia López-Chicón, Tatiana Riba-Tietz, Oscar Fariñas, Pablo-Eduardo Gelber, Ricardo-Pedro Casaroli-Marano, Anna Vilarrodona   +5 more
doaj   +1 more source

Fresh Osteochondral Allograft Transplantation in Osteochondritis Dissecans in the Knee Joint

Life, 2021
Osteochondritis dissecans (OCD) is a chronic and painful joint condition that can occur from childhood through to adult life. Microtrauma, vascular insufficiency, or abnormal endochondral ossification are the most common causes of OCD.
Tommaso Roberti di Sarsina, Michele Fiore, Vito Coco, Marco Govoni, Leonardo Vivarelli, Nicola Rani, Nicolandrea Del Piccolo, Dante Dallari   +7 more
doaj   +1 more source

Comparison of a fast track protocol and standard care after hip arthroplasty in the reduction of the length of stay and the early weight-bearing resumption: study protocol for a randomized controlled trial

Trials, 2021
Background To date, hip arthroplasty is one of the most commonly performed surgical procedures, with growing worldwide demand. In recent decades, major progress made in terms of surgical technique, biomechanics, and tribology knowledge has contributed to
Martina Rocchi, Cesare Stagni, Marco Govoni, Alessandro Mazzotta, Leonardo Vivarelli, Antonella Orlandi Magli, Mariada Perrone, Maria Grazia Benedetti, Dante Dallari   +8 more
doaj   +1 more source

Xenofree generation of limbal stem cells for ocular surface advanced cell therapy

Stem Cell Research & Therapy, 2019
Background Limbal stem cells (LSC) sustain the corneal integrity and homeostasis. LSC deficiency (LSCD) leads to loss of corneal transparency and blindness. A clinical approach to treat unilateral LSCD comprises autologous cultured limbal epithelial stem
Nuria Nieto-Nicolau, Eva M. Martínez-Conesa, Alba M. Velasco-García, Caterina Aloy-Reverté, Anna Vilarrodona, Ricardo P. Casaroli-Marano   +5 more
doaj   +1 more source

Chemosensitivity testing of revived fresh-frozen biopsies using digital speckle holography [PDF]

arXiv, 2023
Enrolling patients in clinical trials to obtain fresh tumor biopsies to profile anticancer agents can be slow and expensive. However, if flash-frozen biopsies can be thawed to produce viable living tissue with relevant biodynamic profiles, then a large reservoir of tissue-banked samples could become available for phenotypic library building.
arxiv  

Excitable dynamics driven by mechanical feedback in biological tissues [PDF]

arXiv, 2023
Pulsatory activity patterns, driven by mechanochemical feedback, are prevalent in many biological systems. Here we present a theoretical framework to elucidate the mechanical origin and regulation of pulsatile activity patterns within multicellular tissues.
arxiv